1. John knows nothing of Sam's clones or Sam's powers.
  2. Sam is not as limited as in other alternate universes.
  3. Kale is the most powerful documented entity to the cannon.
  4. Duncan is somewhat friends with Sam but does not know of his powers or clones. Duncan also is a completely normal person with no special powers.
  5. Alternate characters can be canon in the main story.
  6. Universes are travelable unless completely alternate.